Our Company
Zentalis develops small molecule therapeutics with differentiated product profiles for a broad range of cancers.
Utilizing our Integrated Discovery Engine, the Company is developing a focused pipeline of potentially best-in-class oncology candidates, which include azenosertib, a WEE1 inhibitor for advanced solid tumors. The Company is also leveraging its extensive experience and capabilities across cancer biology and medicinal chemistry to advance its research on protein degraders. Zentalis has operations in San Diego.
Julie Eastland
Chief Executive Officer and Director
Julie Eastland
Chief Executive Officer and Director
Management Team
Julie is the Chief Executive Officer and Director at Zentalis. Prior to joining Zentalis, she served as the Chief Executive Officer and President of Harpoon Therapeutics, a publicly traded clinical stage oncology company, from November 2021, and a member of its Board of Directors from October 2018, until its acquisition by Merck Sharpe & Dohme in March of 2024. Julie previously served as Chief Operating Officer and Chief Financial Officer of ReCode Therapeutics, a privately held genetics medicine company. Prior to ReCode, she served as Chief Financial Officer and Chief Business Officer of Rainier Therapeutics, a privately held biopharmaceutical company focused on bladder cancer. Before Rainier, she was Chief Financial Officer and Chief Business Officer of Cascadian Therapeutics, a publicly traded oncology company acquired by Seattle Genetics in 2018. Prior to Cascadian, Julie served as Chief Financial Officer and Vice President of Finance and Operations of VLST Corporation, a privately held biotechnology company, and held various financial and strategic management positions at publicly traded biotechnology companies including Dendreon and Amgen. Julie is an independent director of Dynavax Technologies Corporation, Lantheus, and Seismic Therapeutic. Julie received an M.B.A. from Edinburgh University Management School and a B.S. in finance from Colorado State University.
Ingmar Bruns, M.D.,
Chief Medical Officer
Ingmar Bruns, M.D.,
Chief Medical Officer
Management Team
Ingmar is Chief Medical Officer of Zentalis. He brings two decades of hematology and oncology experience as a physician and scientist. Prior to joining Zentalis, Ingmar served as Chief Medical Officer of Trillium Therapeutics, a publicly traded clinical stage oncology company, through its acquisition by Pfizer in November 2021, after which he served in clinical development roles at Pfizer, most recently as Development Head, Hematologic Malignancies, Pfizer Global Product Development. Ingmar previously served as the Senior Vice President and Head of Clinical Development at Pieris Pharmaceuticals, a publicly traded clinical stage biotechnology company, where he built and led the clinical development organization. From 2013 through 2017, he led clinical development of several high priority oncology assets at Bayer Pharmaceuticals. Previously, Ingmar served as an attending hematologist and oncologist as well as a physician-scientist at the University Hospital of Dusseldorf in Germany and Albert Einstein College of Medicine in New York. Ingmar has authored over 50 publications in the field of hematology and oncology, including several lead authorships in high impact journals such as Nature Medicine, Blood and Leukemia. He received his M.D. and Ph.D. from the University of Lubeck in Germany.
Kimberly Freeman
Chief Strategy Officer
Kimberly Freeman
Chief Strategy Officer
Management Team
Kimberly is Chief Strategy Officer at Zentalis Pharmaceuticals. Prior to joining Zentalis, Kimberly was Vice President, US Head of DDR Franchise, Oncology at AstraZeneca. She was responsible for overseeing the strategic direction and cross-functional efforts for LYNPARZA® (olaparib) and other therapies targeting the DDR pathway, which is an important hallmark in ovarian and other cancers. Previously, she held various leadership roles at biopharmaceutical companies including Adaptimmune, Boehringer Ingelheim and GlaxoSmithKline. Kimberly has also served on the Alliance for Regenerative Medicine (ARM) Cell Therapy Advisory Committee and has been recognized by Women in Bio as a Female Pioneer in the Life Sciences. After receiving her Bachelor of Science in Biology from Cornell University, she was a Research Scientist in the Department of Hematology/Medical Oncology at Weill Cornell Medical Center and later pursued Microbiology Graduate Studies at SUNY Upstate Medical Center. Kimberly also received Finance and Marketing Certificates from the Wharton School of the University of Pennsylvania.
Interesting Fact: Kimberly is an avid runner, having completed 5 marathons including New York and Boston!
Mark Lackner, PhD
Chief Scientific Officer
Mark Lackner, PhD
Chief Scientific Officer
Management Team
Mark is Chief Scientific Officer. He has over 20 years of experience in oncology drug development with broad experience ranging from target identification through biomarker development in registrational clinical trials. Prior to joining Zentalis, Mark served as SVP and Head of Biology and Translational Sciences at Ideaya Biosciences from 2018 to October 2022. At Ideaya Mark’s group led clinical translational efforts for the PKC inhibitor darovasertib and the MAT2A inhibitor IDE397 and contributed to three development candidate nominations and one IND. Prior to joining IDEAYA, Mark worked at Genentech for 14 years in positions of increasing responsibility in the Oncology Biomarker Development group, most recently as a Director and Principal Scientist. At Genentech his group was accountable for predictive and pharmacodynamic strategies for candidate therapeutics spanning cancer signaling through immuno-oncology, and was accountable for clinical biomarker strategies for over 20 development stage small molecule and antibody agents. His group developed clinical biomarker strategies for immune doublet combinations with the anti-PDL1 antibody Tecentriq, as well as phase III companion diagnostic strategies for the AKT inhibitor Ipatasertib and the MEK and BRAF inhibitors Cobimetinib and Vemurafenib. Mark also provided strategic leadership for the overall breast cancer biomarker strategy within the broader Roche organization. Prior to joining Genentech, Mark worked at Exelixis from 1999 through 2004 in oncology target identification and validation, including the identification of synthetic lethal interactions with the tumor suppressor gene p53. Mark received his PhD from Stanford University in 1997 for studies on genetic analysis of RAS/MAP kinase signaling. He completed postdoctoral studies at UC Berkeley in the laboratory of Joshua Kaplan. He has authored over 60 peer reviewed scientific manuscripts in journals including Nature Medicine, Nature Communications, Journal of Clinical Oncology, Cancer Cell and Clinical Cancer Research.
Interesting Fact: Mark is an avid hiker and has backpacked over 2000 miles through California's High Sierra mountains.
Andrea Paul, JD
Chief Legal Officer and Corporate Secretary
Andrea Paul, JD
Chief Legal Officer and Corporate Secretary
Management Team
Andrea Paul is Chief Legal Officer and Corporate Secretary at Zentalis Pharmaceuticals. Previously, Andrea served as General Counsel and Corporate Secretary of LogicBio Therapeutics, Inc., where she led the company’s legal team and served as a key strategic legal partner in the company’s finance, business development and contractual decision-making matters. Before that, she held positions of increasing responsibility at Akebia Therapeutics, Inc., culminating in the role of Vice President, Legal. While at Akebia, Andrea was a key strategic legal partner in the company’s merger with Keryx Biopharmaceuticals, Inc. as well as in the company’s financing and business development transactions. Prior to Akebia, she served as Senior Corporate Counsel at Momenta Pharmaceuticals, Inc. She began her legal career working as an associate at Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. and Sullivan and Cromwell LLP. She received her JD from Harvard Law School, where she served as the Managing Editor of The Harvard Law Review, and her BA in Art History from Columbia University.
Interesting Fact: Andrea is a dedicated Michael Schumacher fan and still watches replays of his F1 races.
Kyle Rasbach, PhD, PharmD
Chief Business Officer
Kyle Rasbach, PhD, PharmD
Chief Business Officer
Management Team
Kyle Rasbach, PhD, PharmD, is Chief Business Officer at Zentalis Pharmaceuticals. Prior to joining Zentalis, Kyle was a Portfolio Manager for Eventide’s healthcare and life sciences strategies, a Managing Director for Eventide Ventures, and a Senior Research Analyst for other Eventide investments. Kyle has extensive experience in clinical pharmacology, basic science, and healthcare equity research. Prior to joining Eventide, Dr. Rasbach was a Managing Partner at Pappas Capital, a life science venture capital firm that invests across biotechnology, biopharmaceuticals, drug delivery, and medical devices. Earlier in his career, he was an equity research analyst and Vice President at T. Rowe Price, where he managed pharmaceutical, specialty pharmaceutical, and biotechnology investments. Prior to joining T. Rowe, Kyle was an equity research associate and Vice President at Cowen and Company, where he covered global pharmaceutical equities. Kyle holds a PhD in Pharmaceutical and Biomedical Sciences as well as a PharmD from the Medical University of South Carolina; he completed his postdoctoral training in the laboratory of Bruce Spiegelman at the Harvard Medical School. He also holds an MBA from The Citadel and did his undergraduate work at Denison University.
Board of Directors
Julie Eastland
Chief Executive Officer and Director
Julie Eastland
Chief Executive Officer and Director
Board of Directors
Julie is the Chief Executive Officer and Director at Zentalis. Prior to joining Zentalis, she served as the Chief Executive Officer and President of Harpoon Therapeutics, a publicly traded clinical stage oncology company, from November 2021, and a member of its Board of Directors from October 2018, until its acquisition by Merck Sharpe & Dohme in March of 2024. Julie previously served as Chief Operating Officer and Chief Financial Officer of ReCode Therapeutics, a privately held genetics medicine company. Prior to ReCode, she served as Chief Financial Officer and Chief Business Officer of Rainier Therapeutics, a privately held biopharmaceutical company focused on bladder cancer. Before Rainier, she was Chief Financial Officer and Chief Business Officer of Cascadian Therapeutics, a publicly traded oncology company acquired by Seattle Genetics in 2018. Prior to Cascadian, Julie served as Chief Financial Officer and Vice President of Finance and Operations of VLST Corporation, a privately held biotechnology company, and held various financial and strategic management positions at publicly traded biotechnology companies including Dendreon and Amgen. Julie is an independent director of Dynavax Technologies Corporation, Lantheus, and Seismic Therapeutic. Julie received an M.B.A. from Edinburgh University Management School and a B.S. in finance from Colorado State University.
Dave Johnson
Director
Dave Johnson
Director
Board of Directors
Dave has more than 25 years of experience in the biopharmaceutical industry. Most recently, he was chairman of the preclinical precision oncology-focused company, Lengo Therapeutics, which was acquired by Blueprint Medicines in December 2021 in a transaction valued at up to $465M. Prior to Lengo, Dave was CEO of VelosBio an oncology-focused biopharmaceutical company that he founded in December 2017. VelosBio created novel monoclonal antibody-based therapeutics, rapidly moving its lead ROR1-directed antibody-drug-conjugate zilovertamab vedotin from pre-IND through Phase 1 clinical validation leading to the company’s acquisition by Merck in December 2020 for $2.75B. Before Velos, Dave was with Acerta Pharma, an oncology-focused pharmaceutical company focused on covalent small-molecule technology, where he rose to CEO. At Acerta, he built out all facets of the corporation to accelerate the development of Bruton tyrosine kinase inhibitor, acalabrutinib (Calquence™), rapidly moving from early- to late-stage clinical development and launching four global registration-directed trials, including the accelerated approval study that led to acalabrutinib’s first regulatory approval. Dave’s tenure at Acerta culminated in the execution of a strategic transaction with AstraZeneca valued at $7B. He qualifies as an “independent” director in accordance with the listing requirements of Nasdaq.
Scott Myers
Chairperson
Scott Myers
Chairperson
Board of Directors
Scott has worked in the global pharmaceutical and medical technology industries for nearly three decades. He was Chief Executive Officer, President and Director of Viridian Therapeutics, a publicly traded biotechnology company, until November 2023. He was previously Chief Executive Officer and served on the Board of Directors of AMAG Pharmaceuticals, where he led its turnaround and strategic sale to Covis Pharma, S.à.r.l., a pharmaceutical company. Scott served as Chief Executive Officer and Chairman of the Board of Directors of Rainier Therapeutics where he led Rainier’s asset sale of vofatamab to Fusion Pharmaceuticals. Prior to Rainier, Scott served as Chief Executive Officer, President and Director of Cascadian Therapeutics from April 2016 through its acquisition by Seattle Genetics. Scott also serves as Chairperson of the Boards of Directors of Convergent Therapeutics and Dynavax Technologies Corporation. He previously served on the Boards of Directors of Harpoon Therapeutics, Selecta Biosciences, Trillium Therapeutics, and Ironshore Pharmaceuticals. Scott holds a B.A. in biology from Northwestern University and an M.B.A. from the Graduate School of Business (Booth) at the University of Chicago. Scott qualifies as an “independent” director in accordance with the listing requirements of Nasdaq.
Enoch Kariuki, PharmD
Director
Enoch Kariuki, PharmD
Director
Board of Directors
Enoch is an accomplished executive with over a decade of experience in healthcare strategy, life sciences investment banking, venture capital and business development. He currently serves as the President of Endeavor BioMedicines. Previously, he served as Chief Executive Officer of Lengo Therapeutics (acquired by Blueprint Medicines) and as the Chief Financial Officer of VelosBio (acquired by Merck) where he led all finance-related and investor relations functions. Prior to VelosBio, he served as Senior Vice President, Corporate Development at Synthorx, where he led the company’s $151 million IPO, managed relationships with bankers, sell-side equity analysts and investors, and headed the business development process that concluded with the sale of Synthorx to Sanofi for $2.5 billion. Before Synthorx, Enoch was Vice President at H.I.G. Capital, a $40 billion private equity firm, where he invested in and served on the boards of multiple life sciences companies. His other previous roles include Senior Associate at Leerink Partners and Associate Director at UBS Investment Bank. At Leerink and UBS, Enoch advised healthcare companies on equity capital financings, mergers and acquisitions, leveraged buyouts, and recapitalizations.
Enoch completed a Post-Doctoral Fellowship in R&D Strategy and Analytics at Bristol Myers Squibb and was a Pharmacist at CVS Caremark. He holds an MBA from the Tuck School of Business at Dartmouth College and a PharmD from Texas Southern University. Enoch qualifies as an “independent” director in accordance with the listing requirements of Nasdaq.
Jan Skvarka, PhD, MBA
Director
Jan Skvarka, PhD, MBA
Director
Board of Directors
Jan is an Executive Chairman at DEM Biopharma, and a member of the Board of Directors at Monte Rosa Therapeutics (Nasdaq:GLUE). Previously, he was the CEO of Trillium Therapeutics (Nasdaq:TRIL), a clinical stage immuno-oncology company, where he led a highly successful, 360-degree turn-around that produced a leading CD47 drug candidate, while taking the company from a $16M valuation to a $2.3B buy-out by Pfizer in two years. Prior to that, Jan was the CEO of Tal Medical, a private, clinical stage neuroscience company; a partner in the life sciences practice at Bain & Company, Boston; and a manager at Price Waterhouse Corporate Finance in London, UK and Vienna, Austria. He holds a PhD in economics from the University of Economics in Slovakia, and an MBA from Harvard Business School. Jan qualifies as an “independent” director in accordance with the listing requirements of Nasdaq.
Karan Takhar
Director
Karan Takhar
Director
Board of Directors
Karan is a Managing Director and the head of Life Sciences investing at Matrix Capital Management, an investment fund focused on technology and life sciences. He received a Bachelor of Science in Economics and Mathematics from the Massachusetts Institute of Technology. Karan qualifies as an “independent” director in accordance with the listing requirements of Nasdaq.
Luke Walker, M.D.
Director
Luke Walker, M.D.
Director
Board of Directors
Dr. Walker is the Chief Medical Officer of Harpoon Therapeutics, an oncology-focused biopharmaceutical company focused on the development of T-cell engagers in oncology, which was acquired by Merck & Co., Inc., Rahway, NJ, in March 2024. Previously, he was Vice President of Clinical Development at Seagen, where he was the global development lead for TUKYSA (tucatinib) through the program's successful completion of a pivotal registrational trial and successful regulatory approvals. Earlier, Dr. Walker held senior clinical development roles with Cascadian Therapeutics. Dr. Walker began his career as a practicing medical oncologist and hematologist at Providence Regional Medical Center and with the Everett Clinic. He earned his Doctor of Medicine degree, with Special Distinction, from the University of Oklahoma Health Sciences Center.
Luke qualifies as an “independent” director in accordance with the listing requirements of Nasdaq.
Scientific Advisory Board
Anthony Letai, MD, PhD
Harvard Medical School
Anthony Letai, MD, PhD
Harvard Medical School
Scientific Advisory Board
Dr. Anthony Letai is Professor of Medicine at Harvard Medical School and Dana-Farber Cancer Institute. His research focuses on the mechanisms by which cancer cells evade death, and on the application of that knowledge to the selective killing of cancer cells. He joined the faculty of DFCI and Harvard Medical School in 2004. He received his MD and PhD from the University of Chicago. He completed his residency in internal medicine at Brigham and Women’s Hospital, and a fellowship in hematology and oncology at DFCI. He did his postdoctoral research training in the laboratory of Dr. Stanley Korsmeyer.
Ross Levine, MD
Memorial Sloan Kettering Cancer Center
Ross Levine, MD
Memorial Sloan Kettering Cancer Center
Scientific Advisory Board
Dr. Ross Levine is the Director of the Memorial Sloan Kettering Center for Hematologic Malignancies, Laurence Joseph Dineen Chair in Leukemia Research, Member of the Human Oncology and Pathogenesis Program, and Attending Physician at Memorial Sloan Kettering Cancer Center. Dr. Levine’s pioneering research has illuminated the genetic basis of myeloid malignancies, including studies that delineated the role of the JAK-STAT pathway and other oncogenic drivers in the pathogenesis of myeloproliferative neoplasms (MPN) and acute myeloid leukemia (AML). His current efforts focus on the role of mutations in epigenetic modifiers in MPN and AML pathogenesis and therapeutic response, investigation of the role of different signaling pathways in hematopoietic transformation, and mechanisms of resistance to targeted therapies in MPN/AML. He received his MD degree from Johns Hopkins University and his BS from Harvard University.
Funda Meric-Bernstam, MD
MD Anderson Cancer Center
Funda Meric-Bernstam, MD
MD Anderson Cancer Center
Scientific Advisory Board
Funda Meric-Bernstam, M.D., is the Chair of the Department of Investigational Cancer Therapeutics — the Phase 1 Program at The University of Texas MD Anderson Cancer Center. She is a widely recognized Phase 1 trial expert and experimental therapeutics researcher in oncology. Dr. Meric-Bernstam’s clinical research is focused on novel therapeutics, combination therapies, and biomarkers to predict and monitor drug response. Dr. Meric-Bernstam received her MD from the Yale University School of Medicine.
Kwok-Kin Wong, MD, PhD
NYU Langone Health
Kwok-Kin Wong, MD, PhD
NYU Langone Health
Scientific Advisory Board
Dr. Kwok-Kin Wong is a Director, Division of Hematology and Medical Oncology, Anne Murnick Cogan and David H. Cogan Professor of Oncology, Department of Medicine at Laura and Isaac Perlmutter Cancer Center, NYU Langone Health. Dr. Wong obtained his MD, PhD degree at the Columbia University College of Physicians and Surgeons. He was trained in internal medicine at the Massachusetts General Hospital, and hematology and oncology at the Dana-Farber Cancer Institute, both at Harvard Medical School. He was previously the Scientific Director of the Belfer Institute for Applied Cancer Science at Dana-Farber Cancer Institute (DFCI)/ Harvard Medical School. He has authored more than 250 papers and has various patents on the molecular biology of cancer and aging. He is a member of the American Society of Clinical Investigation Association of American Physicians, the nation’s oldest honor society for physician-scientists. He also co-founded G1 Therapeutics.